Abstract
The ratio of X-linked to autosomal diversity was estimated from an analysis of six human genome sequences and found to deviate from the expected value of 0.75. However, the direction of this deviation depends on whether a particular sequence is close to or far from the nearest gene. This pattern may be explained by stronger locally acting selection on X-linked genes compared with autosomal genes, combined with larger effective population sizes for females than for males.
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Acknowledgements
We thank O. Savina for excellent computational support and M. Nachman for comments on the manuscript.
Author information
Affiliations
Arizona Research Laboratories, Division of Biotechnology, University of Arizona, Tucson, Arizona, USA.
- Michael F Hammer
- , August E Woerner
- & Murray P Cox
Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona, USA.
- Michael F Hammer
- & Fernando L Mendez
Department of Mathematics, University of Arizona, Tucson, Arizona, USA.
- Joseph C Watkins
Institute for Human Genetics, University of California San Francisco, San Francisco, California, USA.
- Jeffrey D Wall
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Contributions
M.F.H., A.E.W. and J.D.W. conceived and designed the study and wrote the paper. F.L.M., M.P.C. and J.C.W. designed the statistical analyses. A.E.W. performed bioinformatics and statistical analyses. All authors discussed the results and commented on the manuscript.
Competing interests
The authors declare no competing financial interests.
Corresponding author
Correspondence to Michael F Hammer.
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