News and Views

Mismatch repair prefers exons

A new analysis of cancer genomes identifies a decrease in the mutation burden of exons, but not introns, as compared to expectation. This difference can be explained by preferential recruitment of the DNA mismatch repair machinery to a protein modification that marks exons.

  • Subscribe to Nature Genetics for full access:

    $59

    Subscribe

Additional access options:

Already a subscriber?  Log in  now or  Register  for online access.

References

  1. 1.

    et al. Nature 324, 380–382 (1986).

  2. 2.

    et al. bioRxiv, preprint at (2017).

  3. 3.

    , , , & Nature 532, 264–267 (2016).

  4. 4.

    et al. Nature 532, 259–263 (2016).

  5. 5.

    & Nature 488, 504–507 (2012).

  6. 6.

    et al. Nature 499, 214–218 (2013).

  7. 7.

    et al. Cell 164, 538–549 (2016).

  8. 8.

    et al. Nature 549, 519–522 (2017).

  9. 9.

    et al. Nat. Genet. 49, 1684–1692 (2017).

  10. 10.

    et al. PLoS Comput. Biol. 11, e1004583 (2015).

  11. 11.

    et al. Cell 153, 590–600 (2013).

  12. 12.

    , & Nat. Struct. Mol. Biol. 16, 990–995 (2009).

  13. 13.

    & Science 188, 107–116 (1975).

  14. 14.

    & Cell 170, 534–547 (2017).

  15. 15.

    , & Cell 168, 460–472 (2017).

Download references

Author information

Affiliations

  1. Dashiell J Massey and Amnon Koren are in the Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York, USA.

    • Dashiell J Massey
    •  & Amnon Koren

Authors

  1. Search for Dashiell J Massey in:

  2. Search for Amnon Koren in:

Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Amnon Koren.