Letter

The promise of discovering population-specific disease-associated genes in South Asia

Received:
Accepted:
Published online:

Abstract

The more than 1.5 billion people who live in South Asia are correctly viewed not as a single large population but as many small endogamous groups. We assembled genome-wide data from over 2,800 individuals from over 260 distinct South Asian groups. We identified 81 unique groups, 14 of which had estimated census sizes of more than 1 million, that descend from founder events more extreme than those in Ashkenazi Jews and Finns, both of which have high rates of recessive disease due to founder events. We identified multiple examples of recessive diseases in South Asia that are the result of such founder events. This study highlights an underappreciated opportunity for decreasing disease burden among South Asians through discovery of and testing for recessive disease-associated genes.

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Acknowledgements

We are thankful to the many Indian, Pakistani, Bangladeshi, Sri Lankan, and Nepalese individuals who contributed the DNA samples analyzed here, including the patients with PPD and MPS IVA. We are grateful to A. Basu and P. P. Majumder (National Institute of Biomedical Genomics, Kalyani, India) for early sharing of data. Funding was provided by an NIGMS (GM007753) fellowship to N.N.; a Translational Seed Fund grant from the Dean's Office of Harvard Medical School, and grant HG006399 to D.R.; a Council of Scientific and Industrial Research, Government of India grant to K.T.; support from TIFAC-CORE to S.A.V. and K.S.; and NIGMS grant 115006 to P.M. The study of MPS IVA patients was funded by grants from the Department of Biotechnology, Government of India (BT/PR4224/MED/97/60/2011 to S.S. and S.M.J.) and the Department of Science and Technology, Government of India (SR/WOS-A/LS-83/2011 to S.S.). Funding for the mutation analysis of Indian patients with PPD was provided by the Indian Council of Medical Research (BMS 54/2/2013) to K.M.G. D.R. is supported as an Investigator of the Howard Hughes Medical Institute.

Author information

Author notes

    • Niraj Rai

    Present address: Birbal Sahni Institute of Palaeosciences, Lucknow, India.

    • David Reich
    •  & Kumarasamy Thangaraj

    These authors jointly directed this work.

Affiliations

  1. Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA.

    • Nathan Nakatsuka
    • , Arti Tandon
    •  & David Reich
  2. Harvard-MIT Division of Health Sciences and Technology, Harvard Medical School, Boston, Massachusetts, USA.

    • Nathan Nakatsuka
  3. Department of Biological Sciences, Columbia University, New York, New York, USA.

    • Priya Moorjani
  4. Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.

    • Priya Moorjani
    • , Arti Tandon
    • , Nick Patterson
    •  & David Reich
  5. CSIR-Centre for Cellular and Molecular Biology, Hyderabad, India.

    • Niraj Rai
    •  & Kumarasamy Thangaraj
  6. Anthropological Survey of India, Kolkata, India.

    • Biswanath Sarkar
  7. Department of Medical Genetics, Kasturba Medical College, Manipal University, Manipal, India.

    • Gandham SriLakshmi Bhavani
    •  & Katta Mohan Girisha
  8. Department of Applied Zoology, Mangalore University, Mangalore, India.

    • Mohammed S Mustak
  9. Centre for Human Genetics, Bangalore, India.

    • Sudha Srinivasan
  10. Amity Institute of Biotechnology, Amity University, Noida, India.

    • Amit Kaushik
  11. School of Life Sciences, Manipal University, Manipal, India.

    • Saadi Abdul Vahab
    •  & Kapaettu Satyamoorthy
  12. Fetal Care Research Foundation, Chennai, India.

    • Sujatha M Jagadeesh
  13. Genome Foundation, Hyderabad, India.

    • Lalji Singh
  14. Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts, USA.

    • David Reich

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Contributions

N.N., P.M., D.R., and K.T. conceived the study. N.N., P.M., N.R., B.S., A.T., N.P., and D.R. performed analysis. G.S.B., K.M.G., M.S.M., S.S., A.K., S.A.V., S.M.J., K.S., L.S., and K.T. collected data. N.N., D.R., and K.T. wrote the manuscript with the help of all coauthors.

Competing interests

The authors declare no competing financial interests.

Corresponding authors

Correspondence to David Reich or Kumarasamy Thangaraj.

Supplementary information

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    Supplementary Text and Figures

    Supplementary Figures 1–6, Supplementary Tables 1–4 and 6, and Supplementary Note.

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    Life Sciences Reporting Summary

Excel files

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    Supplementary Table 5

    IBD, FST, and group-specific drift analyses.