Uncertainties in tumor allele frequencies limit power to infer evolutionary pressures

  • Subscribe to Nature Genetics for full access:



Additional access options:

Already a subscriber?  Log in  now or  Register  for online access.


  1. 1.

    , , , & Nat. Genet. 48, 238–244 (2016).

  2. 2.

    et al. Nat. Biotechnol. 31, 213–219 (2013).

  3. 3.

    et al. Nat. Commun. 3, 811 (2012).

Download references


We would like to thank H.S. Kim for helpful discussions and J. Cha for graphics design. J.H.C. was supported by the National Cancer Institute of the NIH under award R21CA191848 and supplement R21CA191848-01A1S1. Research was also partially supported by the National Cancer Institute under award P30CA034196.

Author information


  1. The Jackson Laboratory for Genomic Medicine, Farmington, Connecticut, USA.

    • Javad Noorbakhsh
    •  & Jeffrey H Chuang
  2. Department of Genetics and Genome Sciences, University of Connecticut Health Center, Farmington, Connecticut, USA.

    • Jeffrey H Chuang


  1. Search for Javad Noorbakhsh in:

  2. Search for Jeffrey H Chuang in:

Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Jeffrey H Chuang.

Supplementary information

Word documents

  1. 1.

    Supplementary Note

    Supplementary Note

Text files

  1. 1.

    Supplementary Code

    ipython notebook with code used for computations.