A genome-wide study of fasting insulin, HDL cholesterol and triglycerides, designed to depict insulin resistance, identified 53 independent loci associated with a limited capacity to store fat in a healthy way. The increased power of this multitrait approach provides insights into an otherwise difficult-to-grasp phenotype.
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Heid, I., Winkler, T. A multitrait GWAS sheds light on insulin resistance. Nat Genet 49, 7–8 (2017). https://doi.org/10.1038/ng.3758
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DOI: https://doi.org/10.1038/ng.3758
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