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Reply to 'Olfactory genes in Tibetan wild boar (NG-CR42819)'

Nature Genetics volume 48, pages 973–974 (2016)Cite this article

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Li et al. reply:

Wang et al. claim that, in comparison with the Duroc pig genome, which was assembled using a hybrid strategy that combined BAC and whole-genome shotgun sequence assembly (WGSA)1, the decreased number of olfactory receptor genes in the Tibetan wild boar genome2 may be an illusion caused by limitations of the WGSA strategy. We are aware that WGSA cannot fully recover very recent segmental duplications; therefore, there is a possibility that some olfactory receptor genes in segmental duplication regions could be missed. However, such technical limitation has not prevented the use of WGSA genomes for studies of the olfactory receptor gene family, where expansion of olfactory receptors has been found in numerous cases (turtles3, gecko4, alligator5, duck6, yak7, camels8 and tiger9) when comparing with genomes of relatives generated via a BAC-clone-based or hybrid strategy.

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Figure 1: Comparison of olfactory receptor gene sequencing depth between Tibetan wild boar and Wuzhishan pig.

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Acknowledgements

The work was supported by the Strategic Priority Research Program of the Chinese Academy of Sciences, grant XDB13020600. N.O.O. is thankful for the support of the CAS-TWAS President's Fellowship Program for Doctoral Candidates.

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Authors and Affiliations

  1. Institute of Animal Genetics and Breeding, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, China

    Mingzhou Li, Shilin Tian & Xuewei Li

  2. Novogene Bioinformatics Institute, Beijing, China

    Carol K L Yeung, Yu Lin & Ruiqiang Li

  3. Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA

    Xuming Zhou

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  1. Mingzhou Li
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  2. Carol K L Yeung
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  3. Shilin Tian
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  4. Xuming Zhou
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  5. Yu Lin
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  6. Xuewei Li
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  7. Ruiqiang Li
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Correspondence to Mingzhou Li, Xuewei Li or Ruiqiang Li.

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Li, M., Yeung, C., Tian, S. et al. Reply to 'Olfactory genes in Tibetan wild boar (NG-CR42819)'. Nat Genet 48, 973–974 (2016). https://doi.org/10.1038/ng.3639

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