Two new studies confirm that Plasmodium vivax populations are more diverse than Plasmodium falciparum and identify signs of recent selection at many loci, including those for drug resistance. P. vivax shows a trend of regional adaptations that poses challenges to global efforts to control and eliminate this major cause of relapsing malaria.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
World Health Organization. World Malaria Report 2015 (World Health Organization, 2015).
Price, R.N. et al. Am. J. Trop. Med. Hyg. 77 (Suppl.), 79–87 (2007).
Neafsey, D.E. et al. Nat. Genet. 44, 1046–1050 (2012).
Carlton, J.M. et al. Nature 455, 757–763 (2008).
Chan, E.R. et al. PLoS Negl. Trop. Dis. 6, e1811 (2012).
Winter, D.J. et al. PLoS Negl. Trop. Dis. 9, e0004252 (2015).
Hupalo, D.N. et al. Nat. Genet. 48, 953–958 (2016).
Pearson, R.D. et al. Nat. Genet. 48, 959–964 (2016).
Auburn, S. et al. PLoS One 6, e22213 (2011).
Melnikov, A. et al. Genome Biol. 12, R73 (2011).
Tachibana, S. et al. Nat. Genet. 44, 1051–1055 (2012).
Miller, L.H., Mason, S.J., Clyde, D.F. & McGinniss, M.H. N. Engl. J. Med. 295, 302–304 (1976).
Kwiatkowski, D.P. Am. J. Hum. Genet. 77, 171–192 (2005).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The author declares no competing financial interests.
Rights and permissions
About this article
Cite this article
Kissinger, J. An unsettling picture emerges from population genomic studies of Plasmodium vivax. Nat Genet 48, 825–826 (2016). https://doi.org/10.1038/ng.3630
Published:
Issue Date:
DOI: https://doi.org/10.1038/ng.3630
