How the human brain rapidly builds up its lipid content during brain growth and maintains its lipids in adulthood has remained elusive. Two new studies show that inactivating mutations in MFSD2A, known to be expressed specifically at the blood-brain barrier, lead to microcephaly, thereby offering a simple and surprising solution to an old enigma.
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References
Edmond, J. J. Mol. Neurosci. 16, 181–193 (2001).
Mitchell, R.W. & Hatch, G.M. Prostaglandins Leukot. Essent. Fatty Acids 85, 293–302 (2011).
Nguyen, L.N. et al. Nature 509, 503–506 (2014).
Ben-Zvi, A. et al. Nature 509, 507–511 (2014).
Guemez-Gamboa, A. et al. Nat. Genet. 47, 809–813 (2015).
Alakbarzade, V. et al. Nat. Genet. 47, 814–817 (2015).
Illingworth, D.R. & Portman, O.W. Biochem. J. 130, 557–567 (1972).
Lagarde, M. et al. J. Mol. Neurosci. 16, 201–204 (2001).
Zhang, Y. et al. J. Neurosci. 34, 11929–11947 (2014).
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Betsholtz, C. Lipid transport and human brain development. Nat Genet 47, 699–701 (2015). https://doi.org/10.1038/ng.3348
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DOI: https://doi.org/10.1038/ng.3348
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