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NLRC4 gets out of control

Nature Genetics volume 46, pages 1048–1049 (2014)Cite this article

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The NLRC4 inflammasome mediates the rapid release of proinflammatory cytokines in response to various microbial stimuli, but its role in the pathology of human diseases remains unknown. Two new studies now report gain-of-function mutations in the NLRC4 gene that cosegregate with distinct autoinflammatory syndromes in affected families.

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Figure 1: NAIP-mediated recognition of intracellular flagellin or TTSS components activates NLRC4.

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Authors and Affiliations

  1. Hanif Javanmard Khameneh and Alessandra Mortellaro are in the Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore.,

    Hanif Javanmard Khameneh & Alessandra Mortellaro

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  1. Hanif Javanmard Khameneh
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  2. Alessandra Mortellaro
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Correspondence to Alessandra Mortellaro.

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The authors declare no competing financial interests.

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Khameneh, H., Mortellaro, A. NLRC4 gets out of control. Nat Genet 46, 1048–1049 (2014). https://doi.org/10.1038/ng.3100

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