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Germline PAX5 mutations and B cell leukemia

Nature Genetics volume 45, pages 1104–1105 (2013)Cite this article

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The transcription factor PAX5 is required for normal B cell development and is frequently mutated or deleted in B cell precursor acute lymphoblastic leukemia (B-ALL). A new study demonstrates that germline hypomorphic mutations of PAX5 are associated with susceptibility to B-ALL, implicating PAX5 in a growing list of hematopoietic transcription factors mutated in familial leukemia predisposition syndromes.

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Figure 1: PAX5 is a new inherited B-ALL predisposition gene.

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Authors and Affiliations

  1. Genetics and Molecular Biology Branch, National Human Genome Research Institute, US National Institutes of Health, Bethesda, Maryland, USA

    R Katherine Hyde & P Paul Liu

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  1. R Katherine Hyde
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  2. P Paul Liu
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Correspondence to P Paul Liu.

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The authors declare no competing financial interests.

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Hyde, R., Liu, P. Germline PAX5 mutations and B cell leukemia. Nat Genet 45, 1104–1105 (2013). https://doi.org/10.1038/ng.2778

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