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New pathogenic mechanisms in Burkitt lymphoma

Two studies in this issue identify the landscape of somatic mutations in Burkitt lymphoma and highlight the pathogenic and clinical relevance of inactivating mutations of ID3, an inhibitor of the TCF3 transcription factor.

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Figure 1: Somatic mutations in Burkitt lymphoma frequently target ID3, TCF3 and CCND3.

Debbie Maizels

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Correspondence to Elias Campo.

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Campo, E. New pathogenic mechanisms in Burkitt lymphoma. Nat Genet 44, 1288–1289 (2012). https://doi.org/10.1038/ng.2476

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