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Identification of renal Cd36 as a determinant of blood pressure and risk for hypertension

Abstract

To identify renally expressed genes that influence risk for hypertension, we integrated expression quantitative trait locus (QTL) analysis of the kidney with genome-wide correlation analysis of renal expression profiles and blood pressure in recombinant inbred strains derived from the spontaneously hypertensive rat (SHR). This strategy, together with renal transplantation studies in SHR progenitor, transgenic and congenic strains, identified deficient renal expression of Cd36 encoding fatty acid translocase as a genetically determined risk factor for spontaneous hypertension.

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Figure 1: Genome-wide quantitative trait transcripts analysis of cis eQTLs in the kidney with blood pressure.
Figure 2: Arterial blood pressure and renal expression of wild-type Cd36.

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Acknowledgements

The authors acknowledge funding support to T.W.K. from the US National Institutes of Health, to L.K. and O.V. from the Ministry of Health of the Czech Republic, to M.P., N.H. and T.J.A. from the European Commission within the Sixth Framework Programme through the Integrated Project EURATools, to M.P. from the Grant Agency of the Academy of Sciences of the Czech Republic, to M.P. and V.K. from Ministry of Education of the Czech Republic, and to N.H. from the German Ministry for Science and Education (National Genome Research Network). M.P. is an International Research Scholar of the Howard Hughes Medical Institute. E.P. is a Research Councils UK Fellow.

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Correspondence to Theodore W Kurtz.

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Pravenec, M., Churchill, P., Churchill, M. et al. Identification of renal Cd36 as a determinant of blood pressure and risk for hypertension. Nat Genet 40, 952–954 (2008). https://doi.org/10.1038/ng.164

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