Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letters to Editor
  • Published:

Fibroblast Chalone and Serum Mitogen (Anti-chalone)

Nature New Biology volume 246, pages 111–113 (1973)Cite this article

Abstract

RECENTLY we reported that extracts of diploid human fibroblasts or of the used medium from the cultivation of these cells in vitro contained materials weighing between 30,000 and 50,000 daltons which would specifically inhibit the uptake of tritiated thymidine by WI-38 diploid human fibroblasts in vitro1. This specific and endogenous mitotic inhibitor was termed a fibroblast ‘chalone’, following the proposals of Bullough and Laurence2, 3.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Houck, J. C., Weil, R., and Sharma, V. K., Nature new Biol., 240, 210 (1972).

    Article  CAS  Google Scholar 

  2. Bullough, W., and Laurence, E., Expl Cell Res., 31, 394 (1961).

    Google Scholar 

  3. Bullough, W., and Laurence, E., Expl Cell Res., 33, 176 (1964).

    Article  CAS  Google Scholar 

  4. Houck, J. C., and Cheng, R., J. cell. Physiol., 81, 257 (1973).

    Article  CAS  Google Scholar 

  5. Raff, E., and Houck, J. C., J. cell. Physiol., 74, 235 (1969).

    Article  CAS  Google Scholar 

  6. McDonald, R. A., Surgery, 46, 376 (1959).

    Google Scholar 

  7. Zweifach, B., in The Inflammatory Process (edit, by Zweifach, B., Grant, L., and McCluskey, R.), 161 (Academic Press, New York, 1965).

    Book  Google Scholar 

  8. Howes, E. L., in Connective Tissue (edit, by Asboe-Hansen, G.), 159 (Munksgaard, Copenhagen, 1954).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Biochemical Research Laboratory, Children's Hospital Research Foundation, Washington, DC, 20009

    JOHN C. HOUCK, VISHWA K. SHARMA, SHARMA RICHARD & RICHARD F. CHENG

  2. Department of Child Health and Development, George Washington University Medical School,

    JOHN C. HOUCK, VISHWA K. SHARMA, SHARMA RICHARD & RICHARD F. CHENG

Authors
  1. JOHN C. HOUCK
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. VISHWA K. SHARMA
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. SHARMA RICHARD
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. RICHARD F. CHENG
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

HOUCK, J., SHARMA, V., RICHARD, S. et al. Fibroblast Chalone and Serum Mitogen (Anti-chalone). Nature New Biology 246, 111–113 (1973). https://doi.org/10.1038/newbio246111a0

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1038/newbio246111a0

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing