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Localization and Induction of the Human Thymidine Kinase Gene by Adenovirus 12

Nature New Biology volume 245, pages 172–175 (1973)Cite this article

Abstract

THE development of somatic hybrids between human and mouse cells has resulted in a considerable advance in the analysis of human somatic cells. Gene linkage relationships1,2 and the assignment of genes to human chromosomes3 have been established by enzymatic and cytogenetic analyses of hybrid cells. One of the most interesting and valuable features of somatic hybrids between mouse and human cells is the preferential loss of human chromosomes, in an essentially random manner, from the hybrid4. Using this property, it was shown that the thymidine kinase (TK) gene is on a human E group chromosome4,5. This finding was confirmed and the chromosome identified as E17 (refs 6 and 7).

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Authors and Affiliations

  1. Department of Cancer Studies, University of Birmingham, Birmingham, B15 2TJ, England

    JAMES K. MCDOUGALL

  2. Department of Biology, Yale University, New Haven, Connecticut, 06520

    RAJU KUCHERLAPATI & FRANK H. RUDDLE

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  1. JAMES K. MCDOUGALL
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  2. RAJU KUCHERLAPATI
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  3. FRANK H. RUDDLE
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MCDOUGALL, J., KUCHERLAPATI, R. & RUDDLE, F. Localization and Induction of the Human Thymidine Kinase Gene by Adenovirus 12. Nature New Biology 245, 172–175 (1973). https://doi.org/10.1038/newbio245172a0

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