Abstract
Kimura and Ohta1 have argued that naturally occurring protein polymorphisms are largely due to mutation and random drift, the polymorphisms being the transient manifestation of mutant alleles that are in the process of fixation or loss from the population. This theory has aroused a great deal of controversy. Johnson2 has examined published data with special reference to the above neutral hypothesis and concluded that they seem to be contrary to the following theoretical expectation based on the neutral hypothesis.
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YAMAZAKI, T., MARUYAMA, T. Evidence that Enzyme Polymorphisms are Selectively Neutral. Nature New Biology 245, 140–141 (1973). https://doi.org/10.1038/newbio245140a0
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DOI: https://doi.org/10.1038/newbio245140a0
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