Abstract
TYROSINASE (EC 1.10.3.1.), a key enzyme in melanogenesis, seems to occur in an inactivated form in various tissues1–3. I have examined the possibility that inhibition, rather than a lack of enzymatic activity, is involved in the absence of melanin synthesis in the albino mouse; the c (albino) locus has up to now been considered the structural locus for tyrosinase4,5. I report here the effects on albino and black murine pigment tissue of physical methods and chemical and enzymatic agents which affect tyrosinase activity6–8.
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HEARING, V. Tyrosinase Activity in Subcellular Fractions of Black and Albino Mice. Nature New Biology 245, 81–83 (1973). https://doi.org/10.1038/newbio245081a0
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DOI: https://doi.org/10.1038/newbio245081a0
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