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Non-synchronized Suppression of Postnatal Activity in Non-allelic Genes which Synthesize the Gγ Chain in Human Foetal Haemoglobin

Nature New Biology volume 244, pages 89–90 (1973)Cite this article

Abstract

HUMAN foetal haemoglobin (Hb-F) of the newborn is a heterogeneous protein, with two types of γ chains differing minimally in position 136 which is occupied either by a glycyl residue or by an alanyl residue1. The phenomenon is worldwide and is not limited to specific races or geographic areas2. This and other evidence points to the two types of γ chains, termed the Gγ and Aγ chains, being the products of non-allelic structural genes1.

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References

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Authors and Affiliations

  1. Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California, 91109

    W. A. SCHROEDER

  2. Department of Physiology and Biochemistry, Royal University of Malta and St Luke's Hospital, Msida, Malta

    W. H. BANNISTER & J. L. GRECH

  3. Veterans Administration Hospital, and Department of Pediatrics, Laboratory of Protein Chemistry, Medical College of Georgia, Augusta, Georgia, 30902

    A. K. BROWN, R. N. WRIGHTSTONE & T. H. J. HUISMAN

Authors
  1. W. A. SCHROEDER
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  2. W. H. BANNISTER
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  3. J. L. GRECH
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  4. A. K. BROWN
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  5. R. N. WRIGHTSTONE
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  6. T. H. J. HUISMAN
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SCHROEDER, W., BANNISTER, W., GRECH, J. et al. Non-synchronized Suppression of Postnatal Activity in Non-allelic Genes which Synthesize the Gγ Chain in Human Foetal Haemoglobin. Nature New Biology 244, 89–90 (1973). https://doi.org/10.1038/newbio244089a0

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  • DOI: https://doi.org/10.1038/newbio244089a0

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