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Poly (A) and Poly (U) in Poliovirus Double Stranded RNA

Nature New Biology volume 242, pages 171–174 (1973)Cite this article

Abstract

Poliovirus double stranded RNA (the “replicative form”) contains poly (A) at the 3′-end of the plus (genome-like) strand which is longer than poly (A) found in polio virion RNA. Digestion with 3′-exonuclease, hybridization to labelled poly (A) or poly (U), and affinity chromatography reveal that the minus strand contains 3′-terminal poly (U). These findings may imply that polio RNA replication proceeds through circular structures.

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References

  1. Lai, M. M. C., and Duesberg, P. H., Nature, 235, 383 (1972).

    Article  CAS  Google Scholar 

  2. Armstrong, J. A., Edmonds, M., Nakazato, H., Phillips, B. A., and Vaughan, M. H., Science, 176, 526 (1972).

    Article  CAS  Google Scholar 

  3. Yogo, Y., and Wimmer, E., Proc. US Nat. Acad. Sci., 69, 1877 (1972).

    Article  CAS  Google Scholar 

  4. Johnston, R. E., and Bose, H. R., Proc. US Nat. Acad. Sci., 69, 1514 (1972).

    Article  CAS  Google Scholar 

  5. Green, M., and Cartas, M., Proc. US Nat. Acad. Sci., 69, 791 (1972).

    Article  CAS  Google Scholar 

  6. Gillespie, D., Marshall, S., and Gallo, R. C., Nature New Biology, 236, 227 (1972).

    Article  CAS  Google Scholar 

  7. Lim, L., and Canellakis, E. S., Nature, 227, 710 (1970).

    Article  CAS  Google Scholar 

  8. Kates, J., Cold Spring Harbor Symp. Quant. Biol., 35, 743 (1970).

    Article  CAS  Google Scholar 

  9. Edmonds, M., Vaughan, M. H., and Nakazato, J., Proc. US Nat. Acad. Sci., 68, 1336 (1971).

    Article  CAS  Google Scholar 

  10. Lee, S. Y., Mendecki, J., and Brawerman, G., Proc. US Nat. Acad. Sci., 68, 1331 (1971).

    Article  CAS  Google Scholar 

  11. Sheldon, R., Jurale, C., and Kates, J., Proc. US Nat. Acad. Sci., 69, 417 (1972).

    Article  CAS  Google Scholar 

  12. Darnell, J. E., Philipson, L., Wall, R., and Adesnik, M., Science, 174, 507 (1971).

    Article  CAS  Google Scholar 

  13. Philipson, L., Wall, R., Glickman, G., and Darnell, J. E., Proc. US Nat. Acad. Sci., 68, 2806 (1971).

    Article  CAS  Google Scholar 

  14. Mendecki, J., Lee, S. Y., and Brawerman, G., Biochemistry, 11, 792 (1972).

    Article  CAS  Google Scholar 

  15. Weinberg, R. A., Ben-Ishai, Z., and Newbold, J. E., Nature New Biology, 238, 111 (1972).

    Article  CAS  Google Scholar 

  16. Baltimore, D., in The Biochemistry of Viruses (edit. by Levy, H. B.), 103 (Dekker, New York and London, 1969).

    Google Scholar 

  17. Bishop, J. M., and Levintow, L., Prog. Med. Virol., 13, 1 (1971).

    CAS  Google Scholar 

  18. Wimmer, E., J. Mol. Biol., 68, 537 (1972).

    Article  CAS  Google Scholar 

  19. Cole, C. N., Smoler, D., Wimmer, E., and Baltimore, D., J. Virol., 7, 478 (1971).

    CAS  PubMed  PubMed Central  Google Scholar 

  20. Roy, P., and Bishop, D. H. L., J. Virol., 6, 604 (1972).

    Google Scholar 

  21. Best, M., Evans, B., and Bishop, J. M., Virology, 47, 592 (1972).

    Article  CAS  Google Scholar 

  22. Baltimore, D., Bact. Rev., 35, 235 (1971).

    CAS  PubMed  Google Scholar 

  23. Laskowski, Sr., M., in The Enzymes (edit. by Boyer, P. D.), 4, 313 (Academic Press, New York, 1971).

    Google Scholar 

  24. Wagner, A. F., Bugianesi, R. L., and Shen, T. Y., Biochem. Biophys. Res. Commun., 45, 184 (1971).

    Article  CAS  Google Scholar 

  25. Hershey, A. D., Burgi, E., and Ingraham, L., Proc. US Nat. Acad. Sci., 49, 748 (1963).

    Article  CAS  Google Scholar 

  26. Wu, R., and Taylor, E., J. Mol. Biol., 57, 491 (1971).

    Article  CAS  Google Scholar 

  27. Jackson, D. A., Symons, R. H., and Berg, P., Proc. US Nat. Acad. Sci., 69, 2904 (1972).

    Article  CAS  Google Scholar 

  28. Agol, V. I., Drygin, Y. F., Romanova, L. I., and Bogdanov, A. A., FEBS Lett., 8, 13 (1970).

    Article  Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Microbiology, St Louis University School of Medicine, St Louis, Missouri, 63104

    YOSHIAKI YOGO & ECKARD WIMMER

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  1. YOSHIAKI YOGO
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  2. ECKARD WIMMER
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YOGO, Y., WIMMER, E. Poly (A) and Poly (U) in Poliovirus Double Stranded RNA. Nature New Biology 242, 171–174 (1973). https://doi.org/10.1038/newbio242171a0

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  • DOI: https://doi.org/10.1038/newbio242171a0

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