Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letters to Editor
  • Published:

Induction of B Cell Tolerance by Antigen Specific T Cell Factor

Nature New Biology volume 242, pages 82–84 (1973)Cite this article

Abstract

MANY experimental observations1–9 have suggested that thymus-derived (T) lymphocytes may regulate the activity of bursal-derived (B) lymphocytes in antibody formation (reviewed in refs. 9, 10). T lymphocytes augment antibody production to many but not all antigens11–13 in a process termed “cell cooperation” or the “helper effect”11–14. By contrast, T cells may suppress responsiveness; for example, procedures which deplete T cells, such as adult thymectomy5–7 or the injection of antilymphocyte serum1,2,6, often augment IgM antibody production to thymus-independent antigens. These augmented responses may be prevented by the injection of thymocytes3,15 suggesting that T cells inhibit antibody production in these circumstances. Furthermore, Gershon and Kondo16 found that the induction of tolerance to sheep erythrocytes in B cells was facilitated by T cells.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Baum, J., Lieberman, G., and Frenkel, E. P., J. Immunol., 102, 187 (1969).

    CAS  PubMed  Google Scholar 

  2. Baker, P. J., Barth, R. F., Stashak, P. W., and Amsbaugh, D. F., J. Immunol., 104, 1313 (1970).

    CAS  PubMed  Google Scholar 

  3. Baker, P. J., Stashak, P. W., Amsbaugh, D. F., Prescott, B., and Barth, R. F., J. Immunol., 195, 1581 (1970).

    Google Scholar 

  4. Amstrong, W. D., Diener, E., and Shallam, G. R., J. Exp. Med., 129, 393 (1969).

    Article  Google Scholar 

  5. Okamura, K., and Tada, T., J. Immunol., 106, 1019 (1971).

    Google Scholar 

  6. Kerbel, R. S., and Eidinger, D., J. Immunol., 107, 1682 (1971).

    Google Scholar 

  7. Kerbel, R. S., and Eidinger, D., Europ. J. Immunol., 2, 114 (1972).

    Article  CAS  Google Scholar 

  8. Jacobson, E. B., and Herzenberg, L. A., J. Exp. Med., 135, 1151 (1972).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Allison, A. C., Denman, A. M., and Barnes, R. D., Lancet, ii, 135 (1971).

    Article  Google Scholar 

  10. Katz, D. H., and Benacerraf, B., Adv. Immunol., 15, 1 (1972).

    Article  CAS  PubMed  Google Scholar 

  11. Miller, J. F. A. P., Basten, A., Sprent, J., and Cheers, C., Cell. Immunol., 2, 469 (1971).

    Article  CAS  PubMed  Google Scholar 

  12. Davies, A. J. S., Transpl. Rev., 1, 43 (1969).

    CAS  Google Scholar 

  13. Feldmann, M., and Nossal, G. J. V., Transpl. Rev., 13, 3 (1972).

    CAS  Google Scholar 

  14. Mitchison, N. A., Taylor, R. B., and Rajewsky, K., in Developmental Aspects of Antibody Formation and Structure (edit. by Sterzl, J.), 547 (Publ. House Czech. Acad. Sci., 1970).

    Google Scholar 

  15. Okumura, K., and Tada, T., J. Immunol., 107, 1682 (1971).

    CAS  PubMed  Google Scholar 

  16. Gershon, R. K., and Kondo, K., Immunology, 21, 903 (1971).

    CAS  PubMed  PubMed Central  Google Scholar 

  17. Feldmann, M., and Basten, A., Eur. J. Immunol., 2, 213 (1972).

    Article  CAS  PubMed  Google Scholar 

  18. Feldmann, M., and Basten, A., Nature New Biology, 237, 13 (1972).

    Article  CAS  PubMed  Google Scholar 

  19. Feldmann, M., and Basten, A., J. Exp. Med., 136, 49 (1972).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. Feldmann, M., J. Exp. Med., 136, 737 (1972).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  21. Marbrook, J., Lancet, ii, 1279 (1967).

    Article  Google Scholar 

  22. Diener, E., and Armstrong, W. D., J. Exp. Med., 126, 423 (1969).

    Google Scholar 

  23. Shortman, K., Williams, N., Jackson, H., Russell, P., Byrt, P., and Diener, E., J. Cell. Biol., 48, 556 (1971).

    Article  Google Scholar 

  24. Feldmann, M., J. Exp. Med., 135, 735 (1972).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  25. Cunningham, A. J., and Szenberg, A., Immunology, 14, 599 (1967).

    Google Scholar 

  26. Feldmann, M., and Basten, A., J. Exp. Med., 134, 103 (1971).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  27. Feldmann, M., Europ. J. Immunol., 2, 130 (1972).

    Article  CAS  Google Scholar 

  28. Feldmann, M., and Diener, E., J. Exp. Med., 131, 247 (1970).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  29. Diener, E., and Feldmann, M., Transpl. Rev., 8, 76 (1972).

    CAS  Google Scholar 

  30. Feldmann, M., J. Exp. Med., 136, 532 (1972).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  31. Schrader, J. W., and Feldmann, M., J. Immunol. (in the press).

Download references

Author information

Author notes

  1. MARC FELDMANN

    Present address: Department of Zoology, University College London, Gower Street, London, WC1E 6BT

Authors and Affiliations

  1. Walter and Eliza Hall Institute of Medical Research, Melbourne

    MARC FELDMANN

Authors
  1. MARC FELDMANN
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

address for reprints: Department of Zoology, University College London, Gower Street, London WC1E 6BT.

Rights and permissions

Reprints and permissions

About this article

Cite this article

FELDMANN, M. Induction of B Cell Tolerance by Antigen Specific T Cell Factor. Nature New Biology 242, 82–84 (1973). https://doi.org/10.1038/newbio242082a0

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1038/newbio242082a0

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing