Abstract
PHYTOHAEMAGGLUTININ (PHA) induced transformation of lymphocytes is generally considered specific for thymus derived (T) cells. Thus in neonatally thymectomized mice1 and chickens2 the PHA response is reduced or absent, and studies with chromosome markers3 and anti-theta antibody4,5 indicate that, in the mouse, the PHA responding cells are thymus derived. In Man, absence of the thymus (DiGeorge's syndrome) is associated with a diminished or absent PHA response6,7 which would appear to be evidence for specific T cell transformation. Here we present evidence, however, suggesting that in Man, B cells do respond to PHA.
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PHILLIPS, B., ROITT, I. Evidence for Transformation of Human B Lymphocytes by PHA. Nature New Biology 241, 254–256 (1973). https://doi.org/10.1038/newbio241254a0
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DOI: https://doi.org/10.1038/newbio241254a0
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