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Increase of Nascent Protein Synthesis in Neuromuscular Junction of Rat Diaphragm induced by Denervation

Abstract

ACETYLCHOLINE (ACh) receptors are normally confined to the myoneural junction and nearby area, but after denervation the region sensitive to ACh increases, spreading from the endplate region to encompass the entire surface of the muscle fibre1,2. Denervation increased the incorporation of 14C-L-leucine into the proteolipid peak with high affinity foi ACh and the effect was more marked in the non-plate region than in the strip of the muscle containing the end-plate3.

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KIMURA, M., KIMURA, I. Increase of Nascent Protein Synthesis in Neuromuscular Junction of Rat Diaphragm induced by Denervation. Nature New Biology 241, 114–115 (1973). https://doi.org/10.1038/newbio241114a0

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