Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letters to Editor
  • Published:

Quantitation of Mixed Lymphocyte Reaction by Gene Dosage Phenomenon

Abstract

The mixed lymphocyte reaction (MLR) provides an in vitro method for examining the response to some of the products of the histocompatibility gene complex which may be relevant to the survival of renal allografts1–3. These experiments describe a means of quantitating the response using the gene dose effect and make a preliminary examination of its relevance to renal allograft survival.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

References

  1. Bach, F. H., and Amos, B. D., Science, 156, 1506 (1967).

    Article  CAS  Google Scholar 

  2. Amos, B. D., and Bach, F. H., J. Exp. Med., 128, 623 (1968).

    Article  CAS  Google Scholar 

  3. Amos, B. D., and Yunis, E. J., Cell. Immunol., 2, 517 (1971).

    Article  CAS  Google Scholar 

  4. Boyum, A., Scand. J. Clin. Lab. Invest. (Suppl.), 21, 77 (1968).

    Article  CAS  Google Scholar 

  5. Kissmeyer-Nielson, F., and Thorsby, E., Transpl. Rev., 4, 124 (1971).

    Google Scholar 

  6. Festenstein, H., in Transplantation Antigens and Tissue Typing (edit. by Elves, M. W., and Nisbet, N. N. W.), 165 (Wilding, Shrewsbury, 1969).

    Google Scholar 

  7. Calne, R. Y., Ann. Roy. Coll. Surg., 42, 283 (1968).

    CAS  Google Scholar 

  8. Zoshke, D. C., and Bach, F. H., Science, 172, 1350 (1971).

    Article  Google Scholar 

  9. Viza, D., Sugar, J. R., and Binns, R. M., Nature, 227, 949 (1970).

    Article  CAS  Google Scholar 

  10. Sørenson, S. F., Acta Path. Micro. Biol. Scand., B, 79, 483 (1971).

    Google Scholar 

  11. Wilson, D. B., and Nowell, P. C., J. Exp. Med., 131, 391 (1970).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

BRADLEY, B., EDWARDS, J., DUNN, D. et al. Quantitation of Mixed Lymphocyte Reaction by Gene Dosage Phenomenon. Nature New Biology 240, 54–56 (1972). https://doi.org/10.1038/newbio240054a0

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1038/newbio240054a0

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing