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Repair Enzyme suggested by Mammalian Endonuclease Activity specific for Ultraviolet-irradiated DNA

Nature New Biology volume 239, pages 172–173 (1972)Cite this article

Abstract

THE capacity of an organism to maintain the integrity of the genetic information in its DNA is of critical importance to its survival and the survival of its progeny. Some damage to the DNA is inevitable and it seems that most organisms possess mechanisms for the correction of such damage. There is evidence for one such mechanism, excision-patch repair, in both microorganisms1 and mammalian cells2. The model for this repair process envisions initial endonucleolytic cleavages in the DNA strand, close to the damage, followed by excision of a short oligonucleotide containing the lesion. The resulting gap is then filled and sealed by polymerase and ligase enzymes.

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Author notes

  1. THOMAS P. BRENT

    Present address: St Jude Children's Research Hospital, PO Box 318, 332 N Lauderdale, Memphis, Tennessee

Authors and Affiliations

  1. McGill University Cancer Research Unit, 3655 Drummond Street, Montreal, Quebec

    THOMAS P. BRENT

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  1. THOMAS P. BRENT
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BRENT, T. Repair Enzyme suggested by Mammalian Endonuclease Activity specific for Ultraviolet-irradiated DNA. Nature New Biology 239, 172–173 (1972). https://doi.org/10.1038/newbio239172a0

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  • DOI: https://doi.org/10.1038/newbio239172a0

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