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Effect of Anti-immunoglobulin Antisera on Homograft Rejection in Mice

Nature New Biology volume 237, pages 58–59 (1972)Cite this article

Abstract

HETEROLOGOUS antisera against immunoglobulins or their component protein chains have been shown to inhibit the immune response in a variety of systems. Antibodies against mouse immunoglobulins, for example, inhibit the response of mouse spleen cells cultured in vitro1–3. Antibodies against the heavy chains of chicken IgM (anti-μ), administered during embryonation and again at hatching, have produced agamma-globulinaemia in bursectomized chickens4, apparently by plasma cell line elimination5. Graft-versus-host (GVH) and delayed hypersensitivity reactions have been suppressed in neonatal mice by in vitro pretreatment of injected lymphoid cells with antiserum against light chains6. Similar pretreatment with univalent fragments (Fab) of anti-immunoglobulin antibodies has diminished the GVH reaction in adult mice7.

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Authors and Affiliations

  1. Immunobiology Unit, Department of Botany and Microbiology, Montana State University, Bozeman, Montana

    DEAN D. MANNING & JOHN W. JUTILA

Authors
  1. DEAN D. MANNING
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  2. JOHN W. JUTILA
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MANNING, D., JUTILA, J. Effect of Anti-immunoglobulin Antisera on Homograft Rejection in Mice. Nature New Biology 237, 58–59 (1972). https://doi.org/10.1038/newbio237058a0

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