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Inhibitor of the DNA-dependent DNA Polymerase of Some RNA Tumour Viruses in Feline Sera

Abstract

AN inhibitor of the RNA-dependent DNA polymerases1,2 of mammalian C-type viruses was found in sera from rats bearing transplantable tumours, induced by murine C-type RNA tumour viruses3,4. Partially purified polymerases of murine leukaemia virus3 and feline leukaemia virus (FeLV)4 were shown to be antigenic in rabbits and a rat, respectively. We have detected an inhibitor of the DNA-dependent DNA polymerase5,6 of feline and murine C-type viruses in the sera of cats inoculated in utero and/or postnatally with the Gardner-Arnstein strain of feline sarcoma virus (FSV)7, and in the sera of cats bearing spontaneous sarcomas, lymphomas or carcinomas.

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ROY-BURMAN, P., PAL, B. & GARDNER, M. Inhibitor of the DNA-dependent DNA Polymerase of Some RNA Tumour Viruses in Feline Sera. Nature New Biology 237, 45–47 (1972). https://doi.org/10.1038/newbio237045a0

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