Abstract
SEVERAL reports1–3 have suggested that cholinergic ligands bind to acetylcholinesterase at sites distinct from the active centre. Changeux et al.4 demonstrated that acetylcholine binds to non-catalytic sites as well as to the active centre of the enzyme. Atropine arid 1-hyoscyamine have also been shown to interact with the enzyme at a region distinct from the active site5, 6. We have therefore investigated whether acetylcholine and atropine are bound to the same site and whether this site is related to the acetylcholine receptor.
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References
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KATO, G., TAN, E. & YUNG, J. Allosteric Properties of Acetylcholinesterase. Nature New Biology 236, 185 (1972). https://doi.org/10.1038/newbio236185a0
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DOI: https://doi.org/10.1038/newbio236185a0
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