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Clinical Studies and Physiological Properties of Hopkins-2 Haemoglobin

Nature New Biology volume 234, pages 248–251 (1971)Cite this article

Abstract

HAEMOGLOBIN Hopkins-2 (Ho-2) was discovered in a family in which haemoglobin S was also present1. Independent segregation of the two abnormal haemoglobins provided the first convincing evidence that two genetic loci are concerned with synthesis of the haemoglobin molecule1,2. Subsequently, evidence was obtained that the abnormality in haemoglobin Ho-2 is in the alpha chain3, whereas the lesion in haemoglobin S is in the beta chain of globin. We have reported the structural abnormality in Ho-2 and we now present a revised pedigree and the clinical status of carriers; we attempt to relate these findings to functional abnormalities exhibited by the haemoglobin.

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References

  1. Smith, E. W., and Torbert, J. V., Bull. Johns Hopkins Hospital, 102, 38 (1958).

    CAS  Google Scholar 

  2. Bradley, T. B., jun., Boyer, S. H., and Allen, F. H., jun., Bull. Johns Hopkins Hospital, 108, 75 (1961).

    Google Scholar 

  3. Itano, H. A., and Robinson, E. A., Proc. US Nat. Acad. Sci., 46, 1492 (1960).

    Article  CAS  Google Scholar 

  4. Charache, S., Weatherall, D. J., and Clegg, J. B., J. Clin. Invest., 45, 813 (1966).

    Article  CAS  Google Scholar 

  5. Huisman, T. H. J.,, and Dozy, A. M., J. Chromatag., 19, 160 (1965).

    Article  CAS  Google Scholar 

  6. Charache, S., Mondzac, A. M., and Gessner, U., J. Clin. Invest., 48, 834 (1969).

    Article  CAS  Google Scholar 

  7. Edwards, M. J., and Martin, R. J., J. Appl. Physiol., 21, 1898 (1966).

    Article  CAS  Google Scholar 

  8. Deibler, G. E., Holmes, M. S., Campbell, P. L., and Gans, J., J. Appl. Physiol., 14, 133 (1959).

    Article  CAS  Google Scholar 

  9. Nahas, G. G., Science, 113, 723 (1951).

    Article  CAS  Google Scholar 

  10. Singer, K., and Singer, L., Blood, 8, 1008 (1953).

    CAS  PubMed  Google Scholar 

  11. Itano, H., Arch. Biochem., 47, 148 (1953).

    Article  CAS  Google Scholar 

  12. Itano, H. A., Molecular Structure and Biological Specificity (edit. by Pauling, L., and Itano, H. A.), Pub. No. 2, 166 (Washington, Amer. Inst. Biol. Sci., 1957).

    Google Scholar 

  13. Perutz, M. F., Muirhead, H., Cox, J. M., and Goaman, L. C. G., Nature, 219, 131 (1968).

    Article  CAS  Google Scholar 

  14. Perutz, M. F., and Lehmann, H., Nature, 219, 902 (1968).

    Article  CAS  Google Scholar 

  15. Rosa, J., Oudart, J. L., Pagnier, J., Belkhodja, O., Biogne, J. M., and Labie, D., Abstracts, XII Congress, Int. Soc. Hematology, p. 72 (1968).

    Google Scholar 

  16. Dosik, H., Tatis, B., and Rieder, R. F., Clin. Res., 19, 416 (1971).

    Google Scholar 

  17. Rieder, R. F., Zinkham, W. H., and Holtzman, N. A., Amer. J. Med., 39, 4 (1965).

    Article  CAS  Google Scholar 

  18. Rieder, R. F., J. Clin. Invest., 49, 2369 (1970).

    Article  CAS  Google Scholar 

  19. Monn, E., and Bjark, P., Scand. J. Haemat., 7, 455 (1970).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Hematology Division, Johns Hopkins University, School of Medicine, Baltimore, Maryland

    S. CHARACHE

  2. Max Planck Institute for Experimental Medicine, Göttingen

    W. OSTERTAG & G. VON EHRENSTEIN

Authors
  1. S. CHARACHE
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  2. W. OSTERTAG
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  3. G. VON EHRENSTEIN
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CHARACHE, S., OSTERTAG, W. & EHRENSTEIN, G. Clinical Studies and Physiological Properties of Hopkins-2 Haemoglobin. Nature New Biology 234, 248–251 (1971). https://doi.org/10.1038/newbio234248a0

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