Abstract
SINCE their discovery anti-lymphocyte antisera (ALS) have been widely investigated in order to clarify their mode of action and to determine their usefulness in clinical practice. Briefly, it seems that the efficacy of a particular ALS depends on its mode of production and on the method adopted for testing its immunosuppressive effect. It also seems likely that many ALS have a harmful effect on a population of thymus-dependent (T) lymphocytes1. It is the intention of this paper to confirm this notion and to indicate that other lymphocytes (B cells) are likely to be less affected by ALS.
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BERT, G., FORRESTER, J. & DAVIES, A. Differential Response of B and T Cells to ALS revealed by Electrophoretic Mobility Determinations. Nature New Biology 234, 86–87 (1971). https://doi.org/10.1038/newbio234086a0
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DOI: https://doi.org/10.1038/newbio234086a0
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