Abstract
ALTHOUGH different prostaglandins* may have different pharmacological effects, in general the compounds have the same qualitative action on a given cell type. Investigation1,2 has revealed structure-activity correlations, and the importance of the orientation of the 11 and 15 hydroxyl groups3 is recognized. Molecular model building together with structure-activity data have suggested that prostaglandins are one of a number of classes of drugs and hormones that seem to fit stereochemically into a pre-existing (for example, polypeptide-nucleotide) receptor site4,5. The restraints applied to the prostaglandin molecule to fix it as a stable conformational isomer, or conformer, are little understood and we now wish to indicate the significance of this conformation with respect to interaction with biological membranes.
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RABINOWITZ, I., RAMWELL, P. & DAVISON, P. Conformation of Prostaglandins. Nature New Biology 233, 88–90 (1971). https://doi.org/10.1038/newbio233088a0
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DOI: https://doi.org/10.1038/newbio233088a0
