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Histocompatibility Gene Organization and Mixed Lymphocyte Reaction

Nature New Biology volume 230, pages 271–272 (1971)Cite this article

Abstract

TRANSFORMATION of allogenic lymphocytes in mixed cultures depends chiefly on an incompatibility between the lymphocyte donors at the major histocompatibility locus in man (HL-A), mouse (H-2) and rat (H-l)1. Although the mouse H-2 locus can be divided into several regions each of which controls one or more antigenic specificities2, and two or more subloci control HL-A antigens in man3, it is not known whether all parts of the major histocompatibility locus are equally important in eliciting transformation in mixed lymphocyte cultures. We now show that capacity to elicit lymphocyte transformation is different for different parts of the mouse H-2 locus.

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Authors and Affiliations

  1. Institute of Experimental Biology and Genetics, Czechoslovak Academy of Sciences, Praha

    MILENA RYCHLÍKOVÁ, P. DÉMANT & P. IVÁNYI

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  1. MILENA RYCHLÍKOVÁ
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  2. P. DÉMANT
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  3. P. IVÁNYI
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RYCHLÍKOVÁ, M., DÉMANT, P. & IVÁNYI, P. Histocompatibility Gene Organization and Mixed Lymphocyte Reaction. Nature New Biology 230, 271–272 (1971). https://doi.org/10.1038/newbio230271a0

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