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Is the Ontogeny of Glucuronyl Transferase Adaptive?

Nature New Biology volume 229, pages 216–217 (1971)Cite this article

Abstract

GLUCURONYL transferase (EC 2.4.1.17) catalyses the transfer of glucuronic acid from uridine diphosphate glucuronic acid to a variety of amine, phenolic, and carboxylic aglycones. Although this microsomal enzyme is found in the kidney and the gastrointestinal tract, the liver is the primary site of glucur-onide formation1. In the normal physiological state bilirubin is the principal substrate of this enzyme. Bilirubin must be conjugated with glucuronic acid to be transported from the liver cells to the bile.

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References

  1. Billing, B. H., and Lathe, G. H., Amer. J. Med., 24, 111 (1958).

    Article  CAS  Google Scholar 

  2. Lathe, G. H., and Walker, M., Biochem. J., 70, 705 (1958).

    Article  CAS  Google Scholar 

  3. Dutton, G. J., Biochem. J., 71, 141 (1959).

    Article  CAS  Google Scholar 

  4. Flint, M., Lathe, G. H., Ricketts, J. R., and Silman, G., Quart. J. Exp. Physiol., 49, 66 (1964).

    Article  CAS  Google Scholar 

  5. Childs, B., Sidbury, J. B., and Migeon, C. J., Pediatrics, 23, 903 (1959).

    CAS  PubMed  Google Scholar 

  6. Crigler, J. F., and Najjar, V. A., Pediatrics, 10, 169 (1952).

    PubMed  Google Scholar 

  7. Dutton, G. J., and Ko, V., Biochem. J., 99, 550 (1966).

    Article  CAS  Google Scholar 

  8. Bernstein, R. B., Novy, M. J., Piaseki, G. J., Lester, R., and Jackson, B. T., J. Clin. Invest., 48, 1678 (1969).

    Article  CAS  Google Scholar 

  9. Bernstein, S. E., Russell, E. S., and Keighley, G., Ann. NY Acad. Sci., 149, 475 (1968).

    Article  Google Scholar 

  10. Russell, E. S., and Fondal, E. L., Blood, 6, 892 (1951).

    CAS  PubMed  Google Scholar 

  11. Dutton, G. J., and Storey, I. D. E., in Methods in Enzymology, 4 (edit. by Colwick, S. P., and Kaplan, N. O.), 159 (Academic Press, New York, 1962).

    Google Scholar 

  12. Russell, E. S., and Bernstein, S. E., in Biology of the Laboratory Mouse (edit. by Green, E. L.), 351 (McGraw-Hill, New York, 1966).

    Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Biology, College of William and Mary, Williamsburg, Virginia, 23185

    R. B. CUSWORTH & J. A. SIMONS

Authors
  1. R. B. CUSWORTH
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  2. J. A. SIMONS
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CUSWORTH, R., SIMONS, J. Is the Ontogeny of Glucuronyl Transferase Adaptive?. Nature New Biology 229, 216–217 (1971). https://doi.org/10.1038/newbio229216a0

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