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Peptic ulcer disease in a patient with ankylosing spondylitis receiving a conventional nonsteroidal anti-inflammatory drug

Nature Clinical Practice Rheumatology volume 2, pages 107–111 (2006)Cite this article

Abstract

Background A 42-year-old man with a 10-year history of HLA-B27-positive ankylosing spondylitis presented with upper abdominal pain and nausea after receiving oral ketoprofen 200 mg/day. His gastrointestinal symptoms did not improve with the addition of ranitidine 150 mg twice daily. He had previously responded well to conventional nonsteroidal anti-inflammatory drugs.

Investigations Physical examination, Bath Ankylosing Spondylitis Disease Activity Index, Bath Ankylosing Spondylitis Functional Index, radiography, laboratory tests, upper gastrointestinal endoscopy, histopathologic examination and culture of biopsy specimens.

Diagnosis Helicobacter pylori-positive duodenal ulcer.

Treatment For eradication of H. pylori: omeprazole 20 mg twice daily, clarithromycin 500 mg twice daily and amoxicillin 1 g twice daily for 1 week. For ankylosing spondylitis: diclofenac 150 mg/day in combination with omeprazole 20 mg/day for 2 months.

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Author information

Authors and Affiliations

  1. Teaching Hospital Pellegrin,

    Bernard Bannwarth & Frank Zerbib

  2. Therapeutics at the Victor Segalen University,

    Bernard Bannwarth & Frank Zerbib

  3. Teaching Hospital Saint André,

    Bernard Bannwarth & Frank Zerbib

  4. Gastroenterology at the Victor Segalen University, Bordeaux, France

    Bernard Bannwarth & Frank Zerbib

Authors
  1. Bernard Bannwarth
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  2. Frank Zerbib
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Correspondence to Bernard Bannwarth.

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The authors declare no competing financial interests.

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Bannwarth, B., Zerbib, F. Peptic ulcer disease in a patient with ankylosing spondylitis receiving a conventional nonsteroidal anti-inflammatory drug. Nat Rev Rheumatol 2, 107–111 (2006). https://doi.org/10.1038/ncprheum0098

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