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Ischemic stroke complicating pediatric cardiovascular disease

Abstract

Background After a year of unsuccessful treatment for hypertension, a young boy underwent a stenting procedure for aortic hypoplasia and awoke with hemiparesis and language deficits.

Investigations Neuroimaging, echocardiography, craniocervical vascular imaging and prothrombotic testing.

Diagnosis Procedure-related acute arterial ischemic stroke and malignant cerebral edema with herniation.

Management Anticoagulation with heparin, seizure prophylaxis and neuroprotective care, including external cooling for hyperthermia. Medical management of increased intracranial pressure and hemicraniectomy at 48 h for malignant cerebral edema. Treatment of deep vein thrombosis with inferior vena cava filter was also required. Long term treatments included extensive rehabilitation, aspirin, antiepileptics, antidyskinetics, antidepressants, antihypertensives and cosmetic skull reconstruction.

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Figure 1: Evolution of ischemic stroke complicating cardiac catheterization in a boy with aortic hypoplasia

References

  1. Lynch JK (2004) Cerebrovascular disorders in children. Curr Neurol Neurosci Rep 4: 129–138

    Article  Google Scholar 

  2. deVeber G et al. (2000) Neurologic outcome in survivors of childhood arterial ischemic stroke and sinovenous thrombosis. J Child Neurol 15: 316–324

    Article  CAS  Google Scholar 

  3. Ganesan V et al. (2003) Investigation of risk factors in children with arterial ischemic stroke. Ann Neurol 53: 167–173

    Article  Google Scholar 

  4. Kirkham FJ (1998) Recognition and prevention of neurological complications in pediatric cardiac surgery. Pediatr Cardiol 19: 331–345

    Article  CAS  Google Scholar 

  5. Canadian Paediatric Ischemic Stroke Study Group (2006) Arterial ischemic stroke in Canadian children [abstract]. Ann Neurol 60: S148

  6. Domi T et al. (2002) Frequency and predictors of vasoocclusive strokes associated with congenital heart disease. Ann Neurol 52 (Suppl): S129–S133

    Google Scholar 

  7. Barker PC et al. (2005) Risk factors for cerebrovascular events following fontan palliation in patients with a functional single ventricle. Am J Cardiol 96: 587–591

    Article  Google Scholar 

  8. McQuillen PS et al. (2006) Balloon atrial septostomy is associated with preoperative stroke in neonates with transposition of the great arteries. Circulation 113: 280–285

    Article  Google Scholar 

  9. Miller SP et al. (2004) Preoperative brain injury in newborns with transposition of the great arteries. Ann Thorac Surg 77: 1698–1706

    Article  Google Scholar 

  10. Menache CC et al. (2002) Current incidence of acute neurologic complications after open-heart operations in children. Ann Thorac Surg 73: 1752–1758

    Article  Google Scholar 

  11. Wu YW et al. (2005) Perinatal arterial stroke: understanding mechanisms and outcomes. Semin Neurol 25: 424–434

    Article  Google Scholar 

  12. Kirton A and deVeber G (2006) Therapeutic approaches and advances in pediatric stroke. NeuroRx 3: 133–142

    Article  CAS  Google Scholar 

  13. Monagle P et al. (2004) Antithrombotic therapy in children: The Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest 126 (Suppl): S645–S687

    Article  Google Scholar 

  14. Chabrier S et al. (2000) Stroke in childhood: outcome and recurrence risk by mechanism in 59 patients. J Child Neurol 15: 290–294

    Article  CAS  Google Scholar 

  15. Paediatric Stroke Working Group (online November 2004) Stroke in childhood: clinical guidelines for diagnosis, management and rehabilitation. [http://www.rcplondon.ac.uk/pubs/books/childstroke/] (accessed July 2005)

Download references

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Correspondence to Adam Kirton.

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Kirton, A., deVeber, G. Ischemic stroke complicating pediatric cardiovascular disease. Nat Rev Cardiol 4, 163–166 (2007). https://doi.org/10.1038/ncpcardio0825

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