Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Practice Point
  • Published:

Should all patients with heart failure and left ventricular dysfunction receive combined CRT–ICD therapy?

Nature Clinical Practice Cardiovascular Medicine volume 4, pages 68–69 (2007)Cite this article

boxed-textYpenberg C et al. (2006) Benefit of combined resynchronization and defibrillator therapy in heart failure patients with and without ventricular arrythmias. J Am Coll Cardiol 48: 464–470

Until predictors for a lack of ICD benefit have been identified, all patients with indications for CRT should receive a dual CRT–ICD device

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Ypenberg C et al. (2006) Benefit of combined resynchronization and defibrillator therapy in heart failure patients with and without ventricular arrythmias. J Am Coll Cardiol 48: 464–470

    Article  Google Scholar 

  2. Moss AJ et al. (2002) Prophylactic implantation of a defibrillator in patients with myocardial infarction and reduced ejection fraction. N Engl J Med 346: 877–883

    Article  Google Scholar 

  3. Bardy GH et al. (2005) Amiodarone or an implantable cardioverter-defibrillator for congestive heart failure. N Engl J Med 352: 225–237

    Article  CAS  Google Scholar 

  4. Cleland JG et al. (2005) Longer-term effects of cardiac resynchronization therapy on mortality in heart failure (the CArdiac REsynchronization-Heart Failure [CARE-HF] trial extension phase). Eur Heart J 27: 1928–1932

    Article  Google Scholar 

  5. Bristow MR et al. (2004) Cardiac-resynchronization therapy with or without an implantable defibrillator in advanced chronic heart failure. N Engl J Med 350: 2140–2150

    Article  CAS  Google Scholar 

  6. Hunt SA (2005) ACC/AHA 2005 guideline update for the diagnosis and management of chronic heart failure in the adult: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Update the 2001 Guidelines for the Evaluation and Management of Heart Failure) J Am Coll Cardiol 46: e1–e82

    Article  Google Scholar 

Download references

Acknowledgements

The synopsis was written by Alexandra King, Associate Editor, Nature Clinical Practice.

Author information

Author notes

  1. G Breithardt is also Director of the Department of Molecular Cardiology at the Leibniz-Institute for Arteriosclerosis Research, Münster.

Authors and Affiliations

  1. and G Breithardt is Professor of Medicine and Cardiology and Head of the Department of Cardiology and Angiology, R Gradaus is Consultant and Assistant Professor of Medicine and Cardiology, both at the Hospital of the University of Münster, Germany.,

    Rainer Gradaus & Günter Breithardt

Authors
  1. Rainer Gradaus
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Günter Breithardt
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Günter Breithardt.

Ethics declarations

Competing interests

R Gradaus declared that he has no competing interests. G Breithardt has received research support and honoraria for lectures and has participated on the Advisory Boards of several medical device companies, including Biotronic, Guidant, and Medtronic.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Gradaus, R., Breithardt, G. Should all patients with heart failure and left ventricular dysfunction receive combined CRT–ICD therapy?. Nat Rev Cardiol 4, 68–69 (2007). https://doi.org/10.1038/ncpcardio0739

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ncpcardio0739

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing