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Pharmacogenetics: the outlook for genetic testing in statin therapy

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Correspondence to Daniel I Chasman.

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Supplementary Figure 1

Change in Total Cholesterol (p = 0.0011) The variation in cholesterol reduction with statin therapy in the PRINCE trial.6. Both panels show the distribution of total cholesterol lowering (mg/dl) dependent on the genotype of hmgcr polymorphism #12. (A) Left panel shows the median and interquartile range of cholesterol reduction for the subjects two genotypes observed in the study sample, AA and AT. (B) Right panel shows the mean and distribution of cholesterol reduction for study subjects with the two genotypes in white (AA) and gray (AT). TC, total cholesterol.

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Chasman, D., Ridker, P. Pharmacogenetics: the outlook for genetic testing in statin therapy. Nat Rev Cardiol 2, 2–3 (2005). https://doi.org/10.1038/ncpcardio0071

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