Figure 3: Latrotoxin-CTD comparative analyses support lateral genetic transfers.

From: Eukaryotic association module in phage WO genomes from Wolbachia

Figure 3: Latrotoxin-CTD comparative analyses support lateral genetic transfers.
Figure 3

(a) Phylogeny of phage WO latrotoxin-CTD protein domains and their eukaryotic homologues was constructed by Bayesian analysis of 74 amino acids using the JTT model of evolution. Consensus support values are shown at the nodes. Comparative protein architecture shows that spider venom (b) vertebrate-specific alpha-latrotoxins and (c) invertebrate-specific alpha- and delta-latrotoxins are highly conserved, whereas (d) phage WO are not. WO denotes the specific phage haplotype while genome locus tags are listed in parentheses. Predicted furin cleavage sites, listed in Supplementary Table 3, are illustrated with grey triangles. *A second L. hesperus sequence represents a recently described downstream paralogue with unknown toxin activity32. wNo_10650 is located within phage-associated genes and transposases, indicating a potential genomic rearrangement of a phage region. Architecture is not shown for sequences on incomplete contigs (WOBol1-b, WOAlbB, WODi, WOPipMol and WOVitB) because complete peptide information and specific phage association are unknown. Scale bar, 1,000 amino acids.