Figure 2: Heterogeneity in the chromatin accessibility landscape of CLL.

From: Chromatin accessibility maps of chronic lymphocytic leukaemia identify subtype-specific epigenome signatures and transcription regulatory networks

Figure 2

(a) Genome browser plot showing ATAC-seq signal intensity across the CLL cohort in the vicinity of two genes with a known role in B-cell biology (PAX5 and BCL6). This cohort-level track uses colour-coded percentiles to visualize the observed heterogeneity between samples. The bottom row zooms in on the chromatin accessibility landscape at three specific regulatory regions. (b) Violin plots showing the cohort-wide distribution of chromatin accessibility at promoters (chromatin-accessible regions located within 2,500 bp from the transcription start site) and putative enhancers of genes with a known role in B-cell biology and/or CLL pathogenesis. (c) Unsupervised principal component analysis based on the chromatin accessibility for all 88 samples at each of the 112,298 chromatin-accessible regions in the CLL cohort. Samples are colour coded according to their IGHV mutation status, using <98% germline homology as threshold for classifying a sample as mutated.