Figure 7: Effects of pre-implantation chromosome mosaicism on embryo development and survival.

From: Mouse model of chromosome mosaicism reveals lineage-specific depletion of aneuploid cells and normal developmental potential

Figure 7: Effects of pre-implantation chromosome mosaicism on embryo development and survival.
Figure 7

Reversine-treated embryos formed blastocysts but failed to develop past implantation. Increasing the proportion of control blastomeres in the embryo rescued the lethal phenotype. Numbers represent the viability of early postimplantation embryos that had successfully implanted. Early postimplantation rescue resulted in complete rescue of developmental potential, with E13.5 and live birth rates equivalent to viability at E6.5–7.5.