Figure 5: Loss of reversine-treated cells in postimplantation chimeric mosaic embryos.

From: Mouse model of chromosome mosaicism reveals lineage-specific depletion of aneuploid cells and normal developmental potential

Figure 5: Loss of reversine-treated cells in postimplantation chimeric mosaic embryos.
Figure 5

Chimeras that had been transferred to recipient females were recovered at early postimplantation stages (E6.5–E7.5) and the contribution of reversine-treated cells to the egg cylinder assessed. In these examples, the control clone is marked by the expression of Histone H2B-GFP. In controls, both clones contribute to the embryo. In the reversine chimeras, the majority of each embryo originates from the control clone (demonstrated by the lack of DAPI-positive/GFP-negative cells). Scale bars, 50 μm.