The sheer quantity and complexity of gene expression data can provide extraordinarily accurate descriptions of differences between states of cells, tissues and whole organisms. A compendium of genomic signatures that attempts to describe all biological states has the potential to reveal hidden connections among drugs, genes and diseases.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Indirubin, a small molecular deriving from connectivity map (CMAP) screening, ameliorates obesity-induced metabolic dysfunction by enhancing brown adipose thermogenesis and white adipose browning
Nutrition & Metabolism Open Access 16 March 2020
-
An investigation of biomarkers derived from legacy microarray data for their utility in the RNA-seq era
Genome Biology Open Access 03 December 2014
-
Alignment of gene expression profiles from test samples against a reference database: New method for context-specific interpretation of microarray data
BioData Mining Open Access 31 March 2011
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Chee, M. et al. Science 274, 610–614 (1996).
Marton, M.J. et al. Nat. Med. 4, 1293–1301 (1998).
Hardwick, J.S., Kuruvilla, F.G., Tong, J.K., Shamji, A.F. & Schreiber, S.L. Proc. Natl. Acad. Sci. USA 96, 14866–14870 (1999).
Hughes, T.R. et al. Cell 102, 109–126 (2000).
Stoughton, R.B. & Friend, S.H. Nat. Rev. Drug Discov. 4, 345–350 (2005).
Lamb, J. et al. Science 313, 1929–1935 (2006).
Ramaswamy, S., Ross, K.N., Lander, E.S. & Golub, T.R. Nat. Genet. 33, 49–54 (2003).
Macdonald, M.L. et al. Nat. Chem. Biol. 2, 329–337 (2006).
Giaever, G. et al. Proc. Natl. Acad. Sci. USA 101, 793–798 (2004).
Lum, P.Y. et al. Cell 116, 121–137 (2004).
Parsons, A.B. et al. Nat. Biotechnol. 22, 62–69 (2004).
Parsons, A.B. et al. Cell 126, 611–625 (2006).
Perlman, Z.E. et al. Science 306, 1194–1198 (2004).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Michnick, S. The connectivity map. Nat Chem Biol 2, 663–664 (2006). https://doi.org/10.1038/nchembio1206-663
Issue Date:
DOI: https://doi.org/10.1038/nchembio1206-663
This article is cited by
-
Indirubin, a small molecular deriving from connectivity map (CMAP) screening, ameliorates obesity-induced metabolic dysfunction by enhancing brown adipose thermogenesis and white adipose browning
Nutrition & Metabolism (2020)
-
Identification of nagilactone E as a protein synthesis inhibitor with anticancer activity
Acta Pharmacologica Sinica (2020)
-
An investigation of biomarkers derived from legacy microarray data for their utility in the RNA-seq era
Genome Biology (2014)
-
Alignment of gene expression profiles from test samples against a reference database: New method for context-specific interpretation of microarray data
BioData Mining (2011)