Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

The connectivity map

The sheer quantity and complexity of gene expression data can provide extraordinarily accurate descriptions of differences between states of cells, tissues and whole organisms. A compendium of genomic signatures that attempts to describe all biological states has the potential to reveal hidden connections among drugs, genes and diseases.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Identifying signatures in microarray data.

Katie Ris

References

  1. Chee, M. et al. Science 274, 610–614 (1996).

    Article  CAS  Google Scholar 

  2. Marton, M.J. et al. Nat. Med. 4, 1293–1301 (1998).

    Article  CAS  Google Scholar 

  3. Hardwick, J.S., Kuruvilla, F.G., Tong, J.K., Shamji, A.F. & Schreiber, S.L. Proc. Natl. Acad. Sci. USA 96, 14866–14870 (1999).

    Article  CAS  Google Scholar 

  4. Hughes, T.R. et al. Cell 102, 109–126 (2000).

    Article  CAS  Google Scholar 

  5. Stoughton, R.B. & Friend, S.H. Nat. Rev. Drug Discov. 4, 345–350 (2005).

    Article  CAS  Google Scholar 

  6. Lamb, J. et al. Science 313, 1929–1935 (2006).

    Article  CAS  Google Scholar 

  7. Ramaswamy, S., Ross, K.N., Lander, E.S. & Golub, T.R. Nat. Genet. 33, 49–54 (2003).

    Article  CAS  Google Scholar 

  8. Macdonald, M.L. et al. Nat. Chem. Biol. 2, 329–337 (2006).

    Article  CAS  Google Scholar 

  9. Giaever, G. et al. Proc. Natl. Acad. Sci. USA 101, 793–798 (2004).

    Article  CAS  Google Scholar 

  10. Lum, P.Y. et al. Cell 116, 121–137 (2004).

    Article  CAS  Google Scholar 

  11. Parsons, A.B. et al. Nat. Biotechnol. 22, 62–69 (2004).

    Article  CAS  Google Scholar 

  12. Parsons, A.B. et al. Cell 126, 611–625 (2006).

    Article  CAS  Google Scholar 

  13. Perlman, Z.E. et al. Science 306, 1194–1198 (2004).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Michnick, S. The connectivity map. Nat Chem Biol 2, 663–664 (2006). https://doi.org/10.1038/nchembio1206-663

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nchembio1206-663

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing