Understanding how cytokines interact with multimeric cell receptors to generate signals governing cell behavioral responses is crucial for the development of these promising pharmacological agents. A powerful quantitative approach is reported that was used to analyze the complicated case of binding of the GDNF family member artemin to the heteromeric GFRα3-Ret receptor.
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Katie Ris
References
Airaksinen, M.S. & Saarma, M. Nat. Rev. Neurosci. 3, 383–394 (2002).
Machelska, H., Heppenstall, P.A. & Stein, C. Nat. Med. 9, 1353–1354 (2003).
Schlee, S., Carmillo, P. & Whitty, A. Nat. Chem. Biol. 2, 636–644 (2006).
Janes, K.A. & Lauffenburger, D.A. Curr. Opin. Chem. Biol. 10, 73–80 (2006).
Wiley, H.S, Shvartsman, S.Y. & Lauffenburger, D.A. Trends Cell Biol. 13, 43–50 (2003).
Janes, K.A., Albeck, J.G., Gaudet, S., Sorger, P.K., Lauffenburger, D.A. & Yaffe, M.B. Science 310, 1646–1653 (2005).
Schueler-Furman, O., Glick, E., Segovia, J. & Linial, M. Trends. Pharm. Sci. 27, 72–77 (2006).
Rider, C.C. Biochem. Soc. Trans. 34, 458–460 (2006).
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Lauffenburger, D. Right on cue. Nat Chem Biol 2, 569–570 (2006). https://doi.org/10.1038/nchembio1106-569
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DOI: https://doi.org/10.1038/nchembio1106-569
