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Chemical biology at the crossroads of molecular structure and mechanism

Nature Chemical Biology volume 1, pages 300–303 (2005)Cite this article

Chemical insight into biological function is the holy grail of structural biology. Small molecules are central players as building blocks, effectors and probes of macromolecular structure and function.

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Figure 1: Osmium hexammine is a structural mimic of hexahydrated magnesium ion.
Figure 2: Crystal structure of the Haloarcula marismortui 50S ribosomal subunit5.
Figure 3: Approach to determining physiological activities of kinases by specific sensitization to chemical inhibitors.

Suphoj Chancheaw

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Acknowledgements

I thank K. Berry and J. Cate for helpful discussions and comments on the manuscript.

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  1. Department of Molecular and Cell Biology and the Department of Chemistry, Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, 94705, California, USA

    Jennifer A Doudna

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  1. Jennifer A Doudna
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Doudna, J. Chemical biology at the crossroads of molecular structure and mechanism. Nat Chem Biol 1, 300–303 (2005). https://doi.org/10.1038/nchembio1105-300

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