SGS3 is essential for antiviral silencing and the biogenesis of several classes of siRNAs in plants, but until now no biochemical function has been ascribed to it. Both SGS3 and a viral suppressor of RNA silencing have now been shown to selectively bind 5′ overhang–containing dsRNA, implicating this RNA as a new intermediate in the RNA silencing pathway.
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Elkashef, S., Ding, SW. Possible new RNA intermediate in RNA silencing. Nat Chem Biol 5, 278–279 (2009). https://doi.org/10.1038/nchembio0509-278
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DOI: https://doi.org/10.1038/nchembio0509-278