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Possible new RNA intermediate in RNA silencing

Nature Chemical Biology volume 5, pages 278–279 (2009)Cite this article

SGS3 is essential for antiviral silencing and the biogenesis of several classes of siRNAs in plants, but until now no biochemical function has been ascribed to it. Both SGS3 and a viral suppressor of RNA silencing have now been shown to selectively bind 5′ overhang–containing dsRNA, implicating this RNA as a new intermediate in the RNA silencing pathway.

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Figure 1: A model for SGS3-mediated generation of siRNAs.

References

  1. Fukunaga, R. & Doudna, J.A. EMBO J. 28, 545–555 (2009).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Mourrain, P. et al. Cell 101, 533–542 (2000).

    Article  CAS  PubMed  Google Scholar 

  3. Voinnet, O. Curr. Opin. Plant Biol. 11, 464–470 (2008).

    Article  CAS  PubMed  Google Scholar 

  4. Curaba, J. & Chen, X. J. Biol. Chem. 283, 3059–3066 (2008).

    Article  CAS  PubMed  Google Scholar 

  5. Glick, E. et al. Proc. Natl. Acad. Sci. USA 105, 157–161 (2008).

    Article  CAS  PubMed  Google Scholar 

  6. Li, F. & Ding, S.W. Annu. Rev. Microbiol. 60, 503–531 (2006).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Kumakura, N. et al. FEBS Lett. (in the press).

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  1. Department of Plant Pathology and Microbiology, Samer Elkashef and Shou-Wei Ding are at the Center for Plant Cell Biology, and Graduate Program for Genetics, Genomics and Bioinformatics, University of California, Riverside, California, USA. shou-wei.ding@ucr.edu,

    Samer Elkashef & Shou-Wei Ding

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  1. Samer Elkashef
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  2. Shou-Wei Ding
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Elkashef, S., Ding, SW. Possible new RNA intermediate in RNA silencing. Nat Chem Biol 5, 278–279 (2009). https://doi.org/10.1038/nchembio0509-278

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