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Engineering protease specificity made simple, but not simpler

Nature Chemical Biology volume 4, pages 270–271 (2008)Cite this article

Engineering protease specificity has been a long sought research goal. New findings on OmpT, an outer membrane protease from Escherichia coli, reveal the remarkable success of a simple strategy.

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Figure 1: Surface representation of OmpT viewed from above the plane of the membrane, down the β-barrel axis.

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Authors and Affiliations

  1. Enrico Di Cera is in the Department of Biochemistry and Molecular Biophysics, Washington University Medical School, Box 8231, St. Louis, Missouri 63110, USA. enrico@wustl.edu,

    Enrico Di Cera

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  1. Enrico Di Cera
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Di Cera, E. Engineering protease specificity made simple, but not simpler. Nat Chem Biol 4, 270–271 (2008). https://doi.org/10.1038/nchembio0508-270

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