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Iron-sulfur clusters: ever-expanding roles

Iron-sulfur clusters have critical roles in proteins from diverse organisms and in a broad range of biological processes. Recent discoveries raise exciting challenges for future research by bioinorganic chemists and chemical biologists.

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References

  1. Beinert, H. J. Biol. Inorg. Chem. 5, 2–15 (2000).

    Article  CAS  Google Scholar 

  2. Beinert, H., Holm, R.H. & Münck, E. Science 277, 653–659 (1997).

    Article  CAS  Google Scholar 

  3. Volbeda, A. et al. Nature 373, 580–587 (1995).

    Article  CAS  Google Scholar 

  4. Sazanov, L.A. & Hinchliffe, P. Science (in the press) (2006).

  5. Johnson, D., Dean, D.R., Smith, A.D. & Johnson, M.K. Annu. Rev. Biochem. 74, 247–281 (2005).

    Article  CAS  Google Scholar 

  6. Major, T.A., Burd, H. & Whitman, W.B. FEMS Microbiol. Lett. 239, 117–123 (2004).

    Article  CAS  Google Scholar 

  7. Daniel, R.M. & Danson, M.J. J. Mol. Evol. 40, 559–563 (1995).

    Article  CAS  Google Scholar 

  8. Imlay, J.A. Mol. Microbiol. (in the press) (2006).

  9. Fontecave, M., Mulliez, E. & Ollagnier-de-Choudens, S. Curr. Opin. Chem. Biol. 5, 506–511 (2001).

    Article  CAS  Google Scholar 

  10. Cheek, J. & Broderick, J.B. J. Biol. Inorg. Chem. 6, 209–226 (2001).

    Article  CAS  Google Scholar 

  11. Frey, P.A. & Magnusson, O.T. Chem. Rev. 103, 2129–2148 (2003).

    Article  CAS  Google Scholar 

  12. Sofia, H.J., Chen, G., Hetzler, B.G., Reyes-Spindola, J.F. & Miller, N.E. Nucleic Acids Res. 29, 1097–1106 (2001).

    Article  CAS  Google Scholar 

  13. Fontecave, M., Ollagnier-de-Choudens, S. & Mulliez, E. Chem. Rev. 103, 2149–2166 (2003).

    Article  CAS  Google Scholar 

  14. Jarrett, J.T. Arch. Biochem. Biophys. 433, 312–321 (2005).

    Article  CAS  Google Scholar 

  15. Berkovitch, F., Nicolet, Y., Wan, J.T., Jarrett, J.T. & Drennan, C.L. Science 303, 76–79 (2004).

    Article  CAS  Google Scholar 

  16. Lill, R. & Mülhenhoff, U. Trends Biochem. Sci. 30, 133–141 (2005).

    Article  CAS  Google Scholar 

  17. Fontecave, M., Ollagnier-de-Choudens, S., Py, B. & Barras, F. J. Biol. Inorg. Chem. 10, 713–721 (2005).

    Article  CAS  Google Scholar 

  18. Puccio, H. & Koenig, M. Curr. Opin. Genet. Dev. 12, 272–277 (2002).

    Article  CAS  Google Scholar 

Download references

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Fontecave, M. Iron-sulfur clusters: ever-expanding roles. Nat Chem Biol 2, 171–174 (2006). https://doi.org/10.1038/nchembio0406-171

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