The bacterial transcriptional repressor 6S RNA mimics the DNA contained in a melted promoter and forms specific interactions with the active site of RNA polymerase. A new study shows that, surprisingly, 6S RNA acts as a template for the synthesis of small RNAs, which liberates the polymerase from 6S RNA. Hence, the transcriptional repressor 6S RNA serves as a template for the synthesis of its own de-repressive RNA.
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Kugel, J., Goodrich, J. An RNA transcriptional regulator templates its own regulatory RNA. Nat Chem Biol 3, 89–90 (2007). https://doi.org/10.1038/nchembio0207-89
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DOI: https://doi.org/10.1038/nchembio0207-89
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