Analysis of the multifunctional bone morphogenetic protein (BMP) signaling pathway has been hampered by the lack of specific reagents for discriminating downstream signaling events. A new study uses a novel zebrafish embryo screen to identify dorsomorphin, the first small-molecule inhibitor of BMP signaling, and shows its application in fields as diverse as osteogenesis, developmental patterning and iron homeostasis.
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References
Waite, K.A. & Eng, C. Nat. Rev. Genet. 4, 763–773 (2003).
Nohe, A., Keating, E., Knaus, P. & Petersen, N.O. Cell. Signal. 16, 291–299 (2004).
Yanagita, M. Cytokine Growth Factor Rev. 16, 309–317 (2005).
Yu, P. et al. Nat. Chem. Biol. 4, 33–41 (2008).
Kondo, M. FEBS J. 274, 2960–2967 (2007).
Nemeth, E. & Ganz, T. Annu. Rev. Nutr. 26, 323–342 (2006).
Babitt, J.L. et al. Nat. Genet. 38, 531–539 (2006).
Wang, R. et al. Cell Metab. 2, 399–409 (2005).
Camaschella, C. Blood 106, 3710–3717 (2005).
Anderson, G.J. & Frazer, D.M. Nat. Genet. 38, 503–504 (2006).
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Anderson, G., Darshan, D. Small-molecule dissection of BMP signaling. Nat Chem Biol 4, 15–16 (2008). https://doi.org/10.1038/nchembio0108-15
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DOI: https://doi.org/10.1038/nchembio0108-15
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