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'Turning on' riboswitches to their antibacterial potential

Nature Chemical Biology volume 3, pages 16–17 (2007)Cite this article

Drug-resistant bacteria are a growing challenge to world health, and new approaches to antibiotic development are needed. Riboswitches, regulatory elements of mRNA, are shown to be a potential new target for antibiotic drugs.

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Figure 1: Structural properties of lysine analogs that bind the lysine riboswitch.

References

  1. Lindsay, J.A. & Holden, M.T. Funct. Integr. Genomics 6, 186–202 (2006).

    Article  CAS  Google Scholar 

  2. Blount, K.F., Wang, J.X., Lim, J., Sudarsan, N. & Breaker, R.R. Nat. Chem. Biol. 3, 44–49 (2007)

    Article  CAS  Google Scholar 

  3. Tucker, B.J. & Breaker, R.R. Curr. Opin. Struct. Biol. 15, 342–348 (2005).

    Article  CAS  Google Scholar 

  4. Roth, A., Nahvi, A., Lee, M., Jona, I. & Breaker, RR. RNA 12, 607–619 (2006).

    Article  CAS  Google Scholar 

  5. Vitreschak, A.G., Rodionov, D.A., Mironov, A.A. & Gelfand, M.S. Trends Genet. 20, 44–50 (2004).

    Article  CAS  Google Scholar 

  6. Cromie, M.J., Shi, Y., Latifi, T. & Groisman, E.A. Cell 125, 71–84 (2006).

    Article  CAS  Google Scholar 

  7. Sudarsan, N., Cohen-Chalamish, S., Nakamura, S., Emilsson, G.M. & Breaker, R.R. Chem. Biol. 12, 1325–1335 (2005).

    Article  CAS  Google Scholar 

  8. Sudarsan, N., Wickiser, J.K., Nakamura, S., Ebert, M.S. & Breaker, RR. Genes Dev. 17, 2688–2697 (2003).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Chemistry at the University of Chicago,

    Charles R Lea & Joseph A Piccirilli

  2. Departments of Chemistry and of Biochemistry and Molecular Biology,

    Charles R Lea & Joseph A Piccirilli

  3. Howard Hughes Medical Institute, Center for Integrative Science, University of Chicago, Chicago, 60637, Illinois, USA

    Charles R Lea & Joseph A Piccirilli

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  1. Charles R Lea
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  2. Joseph A Piccirilli
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Lea, C., Piccirilli, J. 'Turning on' riboswitches to their antibacterial potential. Nat Chem Biol 3, 16–17 (2007). https://doi.org/10.1038/nchembio0107-16

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