20(S)-hydroxycholesterol, a naturally occurring oxysterol, activates the Hedgehog signaling pathway by directly binding an allosteric site on Smoothened.
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Marina Corral
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The authors are employees of Genentech Inc., and F.J.D.S. owns shares of Roche.
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Sharpe, H., de Sauvage, F. An oxysterol ligand for Smoothened. Nat Chem Biol 8, 139–140 (2012). https://doi.org/10.1038/nchembio.774
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DOI: https://doi.org/10.1038/nchembio.774
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