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Bioinorganic chemistry

Electrons in Fe-S protein assembly

Iron-sulfur (Fe-S) clusters are among nature's simplest and most versatile agents of electron transfer. Remarkably, their biological assembly involves an obligatory electron transfer event. It is now revealed that parallel but distinct electron transfer pathways are separately required for compartment-specific Fe-S protein maturation.

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Figure 1: Features of electron transfer partners of the ISC (mitochondrial) and CIA (cytosolic) systems required for compartment-specific Fe-S protein maturation.

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Correspondence to Patricia C Dos Santos or Dennis R Dean.

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Dos Santos, P., Dean, D. Electrons in Fe-S protein assembly. Nat Chem Biol 6, 700–701 (2010). https://doi.org/10.1038/nchembio.438

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